RECENT PAPERS

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• An Autophagy-Targeting Chimera Induces Degradation of Androgen Receptor Mutants and AR-v7 in Castration-Resistant Prostate Cancer.

  Cancer Res.

• The N-degron pathway mediates the autophagic degradation of cytosolic mitochondrial DNA during sterile innate immune responses

  Cell Rep

• Oligomerization and a distinct tRNA-binding loop are important regulators of human arginyl-transferase function

  Nat Commun.

• Targeted degradation of SNCA/α-synuclein aggregates in neurodegeneration using the AUTOTAC chemical platform

  Autophagy

• The N-degron pathway mediates lipophagy: The chemical modulation of lipophagy in obesity and NAFLD

  Metabolism

• ECPAS/Ecm29-mediated 26S proteasome disassembly is an adaptive response to glucose starvation

  Cell Rep.

• Targeted degradation of α-synuclein aggregates in Parkinson's disease using the AUTOTAC technology

  Molecular Neurodegeneration

• The Cys-N-degron pathway modulates pexophagy through the N-terminal oxidation and arginylation of ACAD10

  Autophagy

• Monitoring the interactions between N-degrons and N-recognins of the Arg/N-degron pathway

  Methods Enzymol.

• The N-degron pathway: From basic science to therapeutic applications

  BBA-Gene Regulatory Mechanisms

• Monitoring the Activation of Selective Autophagy via N-Terminal Arginylation

  Methods in Molecular Biology

• Analyzing the Interaction of Arginylated Proteins and Nt-Arg-Mimicking Chemical Compounds to N-Recognins

  Methods in Molecular Biology

• Characterization and chemical modulation of p62/SQSTM1/Sequestosome-1 as an autophagic N-recognin

  Methods Enzymol.

• The Cys/N-degron pathway in the ubiquitin-proteasome system and autophagy

  Trends in Cell Biology

• Chemical mimetics of the N-degron pathway alleviate systemic inflammation by activating mitophagy and immunometabolic remodeling

  Experimental&Molecular Medicine

• Methods to detect AUTOphagyTargeting Chimera (AUTOTAC)-mediated Targeted Protein Degradation in Tauopathies

  Bio-protocol

• Phosphorylation of β-catenin Ser60 by polo-like kinase 1 drives the completion of cytokinesis

  EMBO Reports, 22(12), Article e51503

• Mitophagy and endoplasmic reticulum-phagy accelerated by a p62 ZZ ligand alleviates paracetamol-induced hepatotoxicity

  British Journal of Pharmacology

• KLK6/PAR1 Axis Promotes Tumor Growth and Metastasis by Regulating Cross-Talk between Tumor Cells and Macrophages

  Cells

• UBR2 targets myosin heavy chain IIb and IIx for degradation: Molecular mechanism essential for cancer-induced muscle wasting

  Proceedings of the National Academy of Sciences of the United States of America, 119(43), Article e2200215119.

• UBR2 mediates cancer-induced muscle wasting by selectively targeting glycolytic myosin heavy chain for degradation

  PNAS

• Targeted protein degradation via the autophagy-lysosome system: AUTOTAC (AUTOphagy-TArgeting Chimera)

  Autophagy

• Chemical modulation of SQSTM1/p62-mediated xenophagy that targets a broad range of pathogenic bacteria

  Autophagy

• SQSTM1/p62 as a therapeutic target in cancer

  Autophagy Reports

• The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system.

  Nat Commun.

• Phosphorylation of β-catenin Ser60 by polo-like kinase 1 drives the completion of cytokinesis

  EMBO Reports, 22(12), Article e51503.

• The N-terminal cysteine is a dual sensor of oxygen and oxidative stress.

  PNAS

• p62/SQSTM1-induced caspase-8 aggresomes are essential for ionizing radiation-mediated apoptosis

  Cell Death Dis.

• Photodynamic therapy as a potent radiosensitizer in head and neck squamous cell carcinoma

  Cancers, 13(6), 1-13. Article 1193.

• P62-induced cancer-associated fibroblast activation via the Nrf2-ATF6 pathway promotes lung tumorigenesis

  Cancers, 13(4), 1-25. Article 864.

• Dutomycin Induces Autophagy and Apoptosis by Targeting the Serine Protease Inhibitor SERPINB6

  CS Chemical Biology, 16(2), 360-370.

• UBR7 functions with UBR5 in the Notch signaling pathway and is involved in a neurodevelopmental syndrome with epilepsy, ptosis, and hypothyroidism

  American Journal of Human Genetics, 108(1), 134-147.

• Excess of the NF-κB p50 subunit generated by the ubiquitin ligase KPC1 suppresses tumors via PD-L1-and chemokines-mediated mechanisms

  Proceedings of the National Academy of Sciences of the United States of America, 117(47), 29823-29831.

• Lee, Y. S., Kalimuthu, K., Seok Park, Y., Makala, H., Watkins, S. C., Choudry, M. H. A., Bartlett, D. L., Tae Kwon, Y., & Lee, Y. J.

  Journal of Cellular Physiology, 235(10), 6767-6778

• Site-specific ubiquitination of pathogenic huntingtin attenuates its deleterious effects

  Proceedings of the National Academy of Sciences of the United States of America, 117(31), 18661-18669.

• Aggresomal sequestration and STUB1-mediated ubiquitylation during mammalian proteaphagy of inhibited proteasomes

  Proceedings of the National Academy of Sciences of the United States of America, 117(32), 19190-19200.

• CPPF, a novel microtubule targeting anticancer agent, inhibits the growth of a wide variety of cancers

  International Journal of Molecular Sciences, 21(13), 1-17. Article 4800.

• Inhibition of osteoclasts differentiation by CDC2-induced NFATc1 phosphorylation

  Bone, 131, Article 115153.

• Wnt3a Stimulation Promotes Primary Ciliogenesis through β-Catenin Phosphorylation-Induced Reorganization of Centriolar Satellites

  Cell Reports, 30(5), 1447-1462.e5.

• Regulation of reticulophagy by the N-degron pathway Autophagy.

  Autophagy

• Erastin inhibits septic shock and inflammatory gene expression via suppression of the NF-kB Pathway.

  J Clin Med.

• Stress-Induced autophagic engulfment and degradation of the 26s proteasome.

  Methods Enzymology

• Cep131 overexpression promotes centrosome amplification and colon cancer progression by regulating Plk4 stability.

  Cell Death Dis.

• The N-Degron Pathway Mediates ER-phagy

  Mol Cell.

• Mechanistic insight into the regulation of SQSTM1/p62

  Autophagy, 15(4), 735-737.

• Diverse fate of ubiquitin chain moieties : the proximal is degraded with the target, and the distal protects the proximal from removal and recycles.

  PNAS

• Mechanistic insight into the regulation of SQSTM1/p62.

  Autophagy

• Monitoring stress-induced autophagic engulfment and degradation of the 26S proteasome in mammalian cells

  In M. Hochstrasser (Ed.), Ubiquitin-dependent Protein Degradation (pp. 337-366).

• Enhanced anticancer effects of a methylation inhibitor by inhibiting a novel DNMT1 target, CEP 131, in cervical cancer.

  BMB Rep.

• Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition.

  Exp. Mol. Med.

• ZZ-dependent regulation of p62/SQSTM1 in autophagy.

  Nat Com.

• The N-recognin UBR4 of the N-end rule pathway is targeted to and required for the biogenesis of the early endosome.

  Journal of Cell Science

• The N-recognin UBR4 of the N-end rule pathway is required for neurogenesis and homeostasis of cell surface proteins.

  PLos one

• Crosstalk between apoptosis and autophagy is regulated by the arginylated BiP/Beclin-1/p62 complex

  Molecular Cancer Research, 16(7), 1077-1091.

• PARK7 modulates autophagic proteolysis through binding to the N-terminally arginylated form of the molecular chaperone HSPA5.

  Autophagy

• N-terminal arginylation generates a bimodal degron that modulates autophagic proteolysis.

  PNAS.

• The endoplasmic reticulum-residing chaperone BiP is short-lived and metabolized through N-terminal arginylation.

  Sci Signal.

• Regulation of autophagic proteolysis by the N-recognin SQSTM1/p62 of the N-end rule pathway.

  Autophagy.

• The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy.

  Trends Biochem Sci.

• Crosstalk and Interplay between the Ubiquitin-Proteasome System and Autophagy.

  Mol Cells.

• p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis.

  Nat Commun.

• Protein Quality Control by Molecular Chaperones in Neurodegeneration.

  Front Neurosci.

• Glioma-derived cancer stem cells are hypersensitive to proteasomal inhibition.

  EMBO Rep.

• The arginylation branch of the N-end rule pathway positively regulates cellular autophagic flux and clearance of proteotoxic proteins.

  Autophagy

• p62- and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome.

  Proc Natl Acad Sci U S A.

• Ablation of Arg-tRNA-protein transferases results in defective neural tube development.

  BMB Rep.

• Numerous proteins with unique characteristics are degraded by the 26S proteasome following monoubiquitination.

  Proc Natl Acad Sci U S A,

• TRAIL-Induced Caspase Activation Is a Prerequisite for Activation of the Endoplasmic Reticulum Stress-Induced Signal Transduction Pathways

  Journal of Cellular Biochemistry, 117(5), 1078-1091.

• Modulation of SQSTM1/p62 activity by N-terminal arginylation of the endoplasmic reticulum chaperone HSPA5/GRP78/BiP.

  Autophagy

• Cancer Stem Cells Protect Non-Stem Cells from Anoikis: Bystander Effects.

  J Cell Biochem

• Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy

  autophagy

• Secretory TRAIL-armed Natural Killer Cell-based Therapy: In Vitro and In Vivo Colorectal Peritoneal Carcinomatosis Xenograft.

  Mol Cancer Ther.

• Hypoxia promotes synergy between mitomycin C and bortezomib through a coordinated process of Bcl-xL phosphorylation and mitochondrial translocation of p53.

  Mol. Cancer Res. (in press)

• Pharmacological modulation of the N-end rule pathway and its therapeutic implications.

  Trends Pharm. Sci. (TiPS) S0165-6147(15)00154-6.

• Molecular mechanisms controlling asymmetric and symmetric self-renewal of cancer stem cells.

  J. Anal. Sci. Tech. (in press)

• Amino-terminal arginylation as a degradation signal for selective autophagy.

  BMB Reports 48:487-488.

• TRAIL-induced caspase activation is a prerequisite for activation of the endoplasmic reticulum stress-induced signal transduction pathways.

  Cell. Biochem. (Jul 24. doi: 10.1002/jcb.25289, Epub ahead of print)

• Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding.

  Nat Cell Biol. 2015 Jun 15. doi: 10.1038/ncb3177.

• PEGylated Fmoc-amino acid conjugates as effective nanocarriers for improved drug delivery.

  Mol. Pharmaceutics (in press)

• KPC1-Mediated Ubiquitination and Proteasomal Processing of NF-κB1 p105 to p50 Restricts Tumor Growth.

  Cell. 2015 Apr 9;161(2):333-47. doi: 10.1016/j.cell.2015.03.001.

• Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.

  Exp Mol Med. 2015 Mar 13;47:e147. doi: 10.1038/emm.2014.117.

• HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells.

  Cell Signaling, 27:293-305.

• Role of the ubiquitin ligase KPC1 in NF-κB activation and tumor suppression.

  J. Anal. Sci. Tech. (in press)

• Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy

  Autophagy (in press)

• Role of Bcl-xL/Beclin-1 in synergistic apoptotic effects of secretory TRAIL-armed adenovirus in combination with mitomycin C and hyperthermia on colon cancer cells.

  Apoptosis 19:1603-1615.

• Role of AMP-activated protein kinase in crosstalk between apoptosis and autophagy in human colon cancer.

  Cell Death Disease e1504. doi: 10.1038/cddis.2014.463.

• STK295900, a Dual Inhibitor of Topoisomerase 1 and 2, Induces G2 Arrest in the Absence of DNA Damage

  PLoS ONE, 8(1), Article e53908.

• UBR4, an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy.

  Proc. Natl. Acad. Sci. USA 110:3800-3805.

• The N-end rule proteolytic system in autophagy.

  Autophagy

• The N-end rule and retroviral infection: no effect on integrase.

  Virology J.

• Signaling mechanism of tumor cell-induced upregulation of E3 ubiquitin ligase UBR2/E3?-II.

  FASEB J.

• Proteomic analysis reveals that CD147/EMMPRIN confers chemoresistance in cancer stem cell-like cells.

  Proteomics

• Molecular characteristics of cancer stem-like cells derived from human breast cancer cells.

  Anticancer Res. 33:763-777

• Hyperthermia enhances mapatumumab-induced apoptotic death through ubiquitin-mediated degradation of cellular FLIP(long) in human colon cancer cells.

  Cell Death Diseases.

• Cloning, sequencing and expression of a minor protease-encoding gene from Serratia marcescens ATCC 21074.

  Gene 125:75-80.

• UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells

  PLoS ONE, 7(5), Article e37414.

• Is the Cassie-Baxter formula relevant?

  Langmuir, 26(22), 17528-17531.

• UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination

  Proceedings of the National Academy of Sciences of the United States of America, 107(5), 1912-1917.

• Loss of Ubr1 promotes aneuploidy and accelerates B-cell lymphomagenesis in TLX1/HOX11-transgenic mice

  Oncogene, 25(42), 5752-5763

• Loss of Ubr2, an E3 ubiquitin ligase, leads to chromosome fragility and impaired homologous recombinational repair

  Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 596(1-2 SPEC. ISS.), 64-75.

• Erratum: Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome)

  Nature Genetics (2005) 37 (1345-1350)

• Pretreatment of acetylsalicylic acid promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by down-regulating BCL-2 gene expression

  Journal of Biological Chemistry, 280(49), 41047-41056.

• Recent studies of the n-end rule pathway.

  FASEB Journal, 11(9), A995.

• Expression of hepatitis B virus polyherase gene in E. coli..

  Biotechnol Lett 15(8), 821-826

• Cloning, sequencing, and expression of a minor protease-encoding gene from Serratia marcescens ATCC21074.

  Gene . 125(1):75-80