RECENT PAPERS

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• The N-degron pathway mediates lipophagy: The chemical modulation of lipophagy in obesity and NAFLD

  Metabolism

• ECPAS/Ecm29-mediated 26S proteasome disassembly is an adaptive response to glucose starvation

  Cell Rep.

• Targeted degradation of α-synuclein aggregates in Parkinson's disease using the AUTOTAC technology

  Molecular Neurodegeneration

• The Cys-N-degron pathway modulates pexophagy through the N-terminal oxidation and arginylation of ACAD10

  Autophagy

• Monitoring the interactions between N-degrons and N-recognins of the Arg/N-degron pathway

  Methods Enzymol.

• The N-degron pathway: From basic science to therapeutic applications

  BBA-Gene Regulatory Mechanisms

• Monitoring the Activation of Selective Autophagy via N-Terminal Arginylation

  Methods in Molecular Biology

• Analyzing the Interaction of Arginylated Proteins and Nt-Arg-Mimicking Chemical Compounds to N-Recognins

  Methods in Molecular Biology

• Characterization and chemical modulation of p62/SQSTM1/Sequestosome-1 as an autophagic N-recognin

  Methods Enzymol.

• The Cys/N-degron pathway in the ubiquitin-proteasome system and autophagy

  Trends in Cell Biology

• Chemical mimetics of the N-degron pathway alleviate systemic inflammation by activating mitophagy and immunometabolic remodeling

  Experimental&Molecular Medicine

• Methods to detect AUTOphagyTargeting Chimera (AUTOTAC)-mediated Targeted Protein Degradation in Tauopathies

  Bio-protocol

• Mitophagy and endoplasmic reticulum-phagy accelerated by a p62 ZZ ligand alleviates paracetamol-induced hepatotoxicity

  British Journal of Pharmacology

• KLK6/PAR1 Axis Promotes Tumor Growth and Metastasis by Regulating Cross-Talk between Tumor Cells and Macrophages

  Cells

• UBR2 mediates cancer-induced muscle wasting by selectively targeting glycolytic myosin heavy chain for degradation

  PNAS

• Targeted protein degradation via the autophagy-lysosome system: AUTOTAC (AUTOphagy-TArgeting Chimera)

  Autophagy

• Chemical modulation of SQSTM1/p62-mediated xenophagy that targets a broad range of pathogenic bacteria

  Autophagy

• SQSTM1/p62 as a therapeutic target in cancer

  Autophagy Reports

• The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system.

  Nat Commun.

• The N-terminal cysteine is a dual sensor of oxygen and oxidative stress.

  PNAS

• p62/SQSTM1-induced caspase-8 aggresomes are essential for ionizing radiation-mediated apoptosis

  Cell Death Dis.

• Regulation of reticulophagy by the N-degron pathway Autophagy.

  Autophagy

• Erastin inhibits septic shock and inflammatory gene expression via suppression of the NF-kB Pathway.

  J Clin Med.

• Stress-Induced autophagic engulfment and degradation of the 26s proteasome.

  Methods Enzymology

• Cep131 overexpression promotes centrosome amplification and colon cancer progression by regulating Plk4 stability.

  Cell Death Dis.

• The N-Degron Pathway Mediates ER-phagy

  Mol Cell.

• Diverse fate of ubiquitin chain moieties : the proximal is degraded with the target, and the distal protects the proximal from removal and recycles.

  PNAS

• Mechanistic insight into the regulation of SQSTM1/p62.

  Autophagy

• Enhanced anticancer effects of a methylation inhibitor by inhibiting a novel DNMT1 target, CEP 131, in cervical cancer.

  BMB Rep.

• Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition.

  Exp. Mol. Med.

• ZZ-dependent regulation of p62/SQSTM1 in autophagy.

  Nat Com.

• The N-recognin UBR4 of the N-end rule pathway is targeted to and required for the biogenesis of the early endosome.

  Journal of Cell Science

• The N-recognin UBR4 of the N-end rule pathway is required for neurogenesis and homeostasis of cell surface proteins.

  PLos one

• PARK7 modulates autophagic proteolysis through binding to the N-terminally arginylated form of the molecular chaperone HSPA5.

  Autophagy

• N-terminal arginylation generates a bimodal degron that modulates autophagic proteolysis.

  PNAS.

• The endoplasmic reticulum-residing chaperone BiP is short-lived and metabolized through N-terminal arginylation.

  Sci Signal.

• Regulation of autophagic proteolysis by the N-recognin SQSTM1/p62 of the N-end rule pathway.

  Autophagy.

• The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy.

  Trends Biochem Sci.

• Crosstalk and Interplay between the Ubiquitin-Proteasome System and Autophagy.

  Mol Cells.

• p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis.

  Nat Commun.

• Protein Quality Control by Molecular Chaperones in Neurodegeneration.

  Front Neurosci.

• Glioma-derived cancer stem cells are hypersensitive to proteasomal inhibition.

  EMBO Rep.

• The arginylation branch of the N-end rule pathway positively regulates cellular autophagic flux and clearance of proteotoxic proteins.

  Autophagy

• p62- and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome.

  Proc Natl Acad Sci U S A.

• Ablation of Arg-tRNA-protein transferases results in defective neural tube development.

  BMB Rep.

• Numerous proteins with unique characteristics are degraded by the 26S proteasome following monoubiquitination.

  Proc Natl Acad Sci U S A,

• Modulation of SQSTM1/p62 activity by N-terminal arginylation of the endoplasmic reticulum chaperone HSPA5/GRP78/BiP.

  Autophagy

• Cancer Stem Cells Protect Non-Stem Cells from Anoikis: Bystander Effects.

  J Cell Biochem

• Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy

  autophagy

• Secretory TRAIL-armed Natural Killer Cell-based Therapy: In Vitro and In Vivo Colorectal Peritoneal Carcinomatosis Xenograft.

  Mol Cancer Ther.

• Hypoxia promotes synergy between mitomycin C and bortezomib through a coordinated process of Bcl-xL phosphorylation and mitochondrial translocation of p53.

  Mol. Cancer Res. (in press)

• Pharmacological modulation of the N-end rule pathway and its therapeutic implications.

  Trends Pharm. Sci. (TiPS) S0165-6147(15)00154-6.

• Molecular mechanisms controlling asymmetric and symmetric self-renewal of cancer stem cells.

  J. Anal. Sci. Tech. (in press)

• Amino-terminal arginylation as a degradation signal for selective autophagy.

  BMB Reports 48:487-488.

• TRAIL-induced caspase activation is a prerequisite for activation of the endoplasmic reticulum stress-induced signal transduction pathways.

  Cell. Biochem. (Jul 24. doi: 10.1002/jcb.25289, Epub ahead of print)

• Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding.

  Nat Cell Biol. 2015 Jun 15. doi: 10.1038/ncb3177.

• PEGylated Fmoc-amino acid conjugates as effective nanocarriers for improved drug delivery.

  Mol. Pharmaceutics (in press)

• KPC1-Mediated Ubiquitination and Proteasomal Processing of NF-κB1 p105 to p50 Restricts Tumor Growth.

  Cell. 2015 Apr 9;161(2):333-47. doi: 10.1016/j.cell.2015.03.001.

• Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.

  Exp Mol Med. 2015 Mar 13;47:e147. doi: 10.1038/emm.2014.117.

• HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells.

  Cell Signaling, 27:293-305.

• Role of the ubiquitin ligase KPC1 in NF-κB activation and tumor suppression.

  J. Anal. Sci. Tech. (in press)

• Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy

  Autophagy (in press)

• Role of Bcl-xL/Beclin-1 in synergistic apoptotic effects of secretory TRAIL-armed adenovirus in combination with mitomycin C and hyperthermia on colon cancer cells.

  Apoptosis 19:1603-1615.

• Role of AMP-activated protein kinase in crosstalk between apoptosis and autophagy in human colon cancer.

  Cell Death Disease e1504. doi: 10.1038/cddis.2014.463.

• UBR4, an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy.

  Proc. Natl. Acad. Sci. USA 110:3800-3805.

• The N-end rule proteolytic system in autophagy.

  Autophagy

• The N-end rule and retroviral infection: no effect on integrase.

  Virology J.

• Signaling mechanism of tumor cell-induced upregulation of E3 ubiquitin ligase UBR2/E3?-II.

  FASEB J.

• Proteomic analysis reveals that CD147/EMMPRIN confers chemoresistance in cancer stem cell-like cells.

  Proteomics

• Molecular characteristics of cancer stem-like cells derived from human breast cancer cells.

  Anticancer Res. 33:763-777

• Hyperthermia enhances mapatumumab-induced apoptotic death through ubiquitin-mediated degradation of cellular FLIP(long) in human colon cancer cells.

  Cell Death Diseases.

• Cloning, sequencing and expression of a minor protease-encoding gene from Serratia marcescens ATCC 21074.

  Gene 125:75-80.